Chemotherapy radiotherapy palliative -ANC module part 2
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1) A 55yearold woman presents to clinic with a diagnosis of recurrent endometrial cancer. A
fullstaging CT scan shows three lung metastases, all less than 3 cm. Some 6 years ago, she
underwent a hysterectomy with bilateral salpingooophorectomy, bilateral
pelvic and paraaortic lymphadenectomy for a stage I, grade 2 welldifferentiated endometrioid
endometrial carcinoma. Her ECOG performance status is 1.
What is the most appropriate management?
2) Bleomycin
Topoisomerase II inhibitor
Prevention of microtubule disassembly
Inhibition of thymidylate synthase
Causes singlestrand scission of DNA
3) Methotrexate
4) Bleomycin
Cardiac failure
Hand foot syndrome
Neuropathy
Pulmonary fibrosis
5) Doxorubicin
Not known
6) 5flurouracil
Haemorrhagic cystitis
7) A40-year-old woman has recently been diagnosed with ovarian cancer and has received
two cycles of chemotherapy. She presents with decreased urine output,
tingling in the lower limbs and is hard of hearing followingcompletion of the
second cycle. Her blood results show high creatinine and low magnesium.
8) Taxanes
9) This chemotherapy agent is dosed using the serum creatinine
10) Anthracyclines
11) This chemotherapy agent should be used with caution in patients with diabetes mellitus
12) A20-year-old woman is having treatment for a high-risk gestational trophoblastic disease.
She has just finished her second cycle of chemotherapy. 1week later she
presents with feeling unwell with motor weakness, double vision and sore throat
Clinical examination reveals lower limb power of 3/5 and lateral rectus palsy of
right eye, and blood results show myelosuppression.
13) A20-year-old woman had medical treatment for an ectopic pregnancy 15 days ago.She
has been told not to get pregnant for at least 1month following this injection because the
drug has an antifolate action.
14) This chemotherapy agent does not cause myelosupression
15) A49-year-old woman presents with haematuria. She has recently been diagnosedwith
ovarian cancer and has received two cycles of chemotherapy. Cystoscopyreveals
haemorrhagic cystitis.
16) A 42yearold woman has recently been diagnosed with ovarian cancer. She had some
ascites drained a couple of weeks ago, which confirmed the diagnosis, and is now awaiting
the results of staging investigations but was admitted with increased abdominal pain.
She has been given bilateral nephrostomies earlier this week following renal obstruction.
You are working nights on the ward and are asked by the nursing staff to prescribe
analgesia.
Select the single best answer:
17) Paclitaxel
18) A 43yearold woman with a history of endometrial cancer presents with leftsided
hydronephrosis and left loin pain. Her creatinine is 82. A staging CT scan shows a large
pelvic mass with disseminated peritoneal deposits and an isolated liver metastases. A
ureteric stent is inserted successfully, with relief of her symptoms.
Twelve months ago she underwent a total abdominal hysterectomy and bilateral
salpingooophorectomy for a stage 1, grade 3 endometrioid endometrial cancer, and did not
receive adjuvant chemotherapy. Her ECOG performance score is 1.
19) A 60yearold woman is diagnosed to have stage IV ovarian cancer. She wants to know when
death will occur.What is the most appropriate approach to answer her question?
20) Doxorubicin
Nephrotoxicity
21) A40-year-old woman presents with palpitations, numbness and tinglingin
the legs, and alopecia involving allbody hair.She has recently been diagnosed
with ovarian cancer and hasreceived three cycles of chemotherapy. Clinical
examination reveals pulse of 180bpm and normal blood pressure. She is booked
for debulking surgery in 10days.
22) This chemotherapy agent requires pre and posthydration
23) 5Flurouracil
Alkylating agent
24) This chemotherapy agent is associated with a dosedependent risk
of cardiac failure
25) Cisplatin
Crosslink DNA
26) This chemotherapy agent can be administered by both the oral and
intravenous routes
27) An 87yearold lady had radical surgery for vulval cancer 10 days ago. She also has chronic
obstructive pulmonary disease and is a smoker. Postoperatively she has been struggling
with pain and lack of appetite, and is frustrated that she cannot get out of bed without help
because she is feeling too weak. She says she wishes she had never agreed to the
operation and she wants to make sure you do not do anything else to prolong her life.
28) 5Fluorouracil
29) Ifosfamide
30) This chemotherapy agent is associated with hand–foot syndrome and may exacerbate
angina in patients with ischaemic heart disease
31) Bleomycin
32) Paclitaxel
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