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Immunology Test (Part 1)

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1) Which complement protein is the product of all 3 activation pathways

2) Which of the following diseases has a lower incidence/incidence of flare ups in pregnancy?

3) Which of the following is a tumour marker for trophoblastic disease?

4) What is the first immunoglobulin to be synthesised by the neonate?

5) Which immunoglobulin exists as a dimer and is found in secretions such as saliva

6) You are asked to decide on administration of anti‐D immunoglobulin to a 30 year old pregnant patient. A maternal blood test shows the mother to be Rhesus negative with no immune anti‐D. Which of the following situations does not warrant anti‐D immunoglobulin administration?

7) Rhesus D immunoglobin treatment utilises what class of antibody?

8) At what stage of gestation does fetal immunoglobulin M production begin

9) Which of the following best describes the fetus?

10) Which immunoglobulin is the only one capable of crossing the placenta?

11) Which of the following is a tumour marker for ovarian cancer?

12) Which Immunoglobulin (or antibody) is secreted in large amounts in breast milk?

13) With regard to the role of the placenta in preventing immune rejection. Which of the following HLA (Human Leukocyte Antigen) genes are not expressed by cells of the trophoblast?

14) You have just clerked in a patient on the labor ward who has SLE. What type of hypersensitivity reaction is SLE an example of?

15) At what stage of gestation does maternal immunoglobulin G transfer to the fetus start?

16) Which of the following will require Anti‐D administration post partum?

17) With regard to the role of the placenta in preventing immune rejection. Which of the following HLA (Human Leukocyte Antigen) genes is produced at high levels in the maternal interface and  is thought to play an important role in suppressing maternal immune function and preventing immune attack against the fetus?

18) Which immunoglobulin is key to passive neonatal immunity?

19) Which of the following increases in pregnancy?

20) Which of the following cell types act as professional antigen presenter cells (APCs)

21) You are reviewing a patient in the antenatal clinic who has moved to the UK from Bangladesh 1 month ago. She asks about BCG vaccination for her baby. What type of vaccine is the BCG?

22) Which of the following plays an important role in the adaptive immune system?

23) You are called back to see a patient 20 minutes after changing her cannula. The patient has come up in hives and asks if you wore latex gloves as she has a latex allergy. What type of hypersensitivity reaction is this?

24) Haemolytic Disease of the Newborn falls into what type of hypersensitivity reaction?

25) What is the gold standard test for detection of chlamydia?

26) Which complement protein recruits other complement proteins to form MAC (membrane attack complex)?

27) Which of the following cells is considered the basis for the adaptive immune system?

28) Which of the following is suppressed in pregnancy (the suppression of which is thought to aid immune tolerance of the fetus)?

29) Myasthenia Gravis is an example of what type of hypersensitivity reaction?

30) What cell type displays the rhesus antigen in Rhesus positive patients?

31) Macrophages are derived from what type of white blood cell?

32) Which immunoglobulin (or antibody) has the largest molecular weight and has a pentamer structure?

33) Which of the following cytokines have increased production during pregnancy and are thought to enhance fetal survival?

34) The Mantoux test utilises what type of hypersensitvity reaction

35) You see a patient in antenatal clinic who is concerned that she has never had chicken pox and may catch it during pregnancy. You check her Varicella status and she is non‐immune. She asks you about vaccination. What type of vaccine is the varicella vaccine?

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