
Anti‐D Ig Key Points from BCSH Guidelines*
All RhD negative pregnant women who have not been previously sensitised should be
offered routine antenatal prophylaxis with anti‐D Ig (RAADP) either with a single dose
regimen at around 28 weeks, or two‐dose regimen given at 28 and 34 weeks
Following birth, ABO and Rh D typing should be performed on cord blood and if the
baby is confirmed to be D positive, all D negative, previously non‐sensitised, women
should be offered at least 500 IU of anti‐D Ig within 72h following delivery. Maternal
samples should be tested for FMH and additional dose(s) given as guided by FMH tests
Following potentially sensitising events, anti‐D Ig should be administered as soon as
possible and always within 72h of the event. If, exceptionally, this deadline has not been
met some protection may be offered if anti‐D Ig is given up to 10 days after the
sensitising event
In pregnancies <12 weeks gestation, anti‐D Ig prophylaxis is only indicated following
ectopic pregnancy, molar pregnancy, therapeutic termination of pregnancy and in cases
of uterine bleeding where there is repeated, heavy bleeding or associated with
abdominal pain. The minimum dose should be 250 IU. A test for fetomaternal
haemorrhage (FMH) is not required
For potentially sensitising events between 12 and 20 weeks gestation, a minimum dose
of 250 IU should be administered within 72h of the event. A test for FMH is not required
For potentially sensitising events after 20 weeks gestation, a minimum anti‐D Ig dose of
500 IU should be administered within 72h of the event. A test for FMH is required
List of Potentially Sensitising Events
Amniocentesis, chorionic villus biopsy and cordocentesis
APH and PV bleeding in pregnancy
External cephalic version
Abdominal trauma
Ectopic pregnancy
Evacuation of molar pregnancy
Intrauterine death and stillbirth
In‐utero therapeutic interventions (transfusion, surgery, insertion of shunts, laser)
Miscarriage, threatened miscarriage
Therapeutic termination of pregnancy
Delivery
Intra‐operative cell salvage