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molar pregnancy-early pregnancy care part 2

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1)

A woman has undergone surgical management of miscarriage and a partial molar pregnancy
has been confirmed. Referral to a specialist centre is advised.
Where are the three specialist referral centres in the United Kingdom?

2)

. A 21-yr old primiparous woman who has had a previous molar pregnancy is now pregnant
one year later. Her pregnancy appears to be progressing well. How would u manage her
following delivery?

3)

The general practitioner calls to ask about the immediate follow-up of a woman who had a
suction evacuation of a complete molar pregnancy. What is your advice?

4)

A 21-yr old woman attended the hospital at 6 wks of amenorrhea and a +ve home
pregnancy test. A likely miscarriage was diagnosed on USG and she opted for surgical
evacuation. Product of conception demonstrated partial H. mole.

5)

A woman has undergone surgical management of miscarriage and the histology confirms
Gestational Trophoblastic Disease (GTD). What is the expected incidence of GTD in the United
Kingdom?

6)

A woman has been diagnosed with high-risk gestational trophoblastic neoplasia (GTN) and is
about to receive multiagent chemotherapy. What is the expected cure rate?

7)

A woman has attended the gynaecology clinic to discuss a diagnosis of a molar pregnancy.
What is the definitive method of diagnosis?

8) What percentage of partial molar pregnancies consist of tetraploid or mosaic conceptions?

9)

Following appropriate treatment of complete and partial molar pregnancies, what
percentage of women need additional chemotherapy in each case, respectively?

10)

A 43-yr old multiparous woman is diagnosed with gestational neoplastic disease 3 months
following a surgical termination. Her serum HCG is 10,000 mIU/ml. she has 2 small (1 cm)
metastases in the lung

11)

A 35-year-old woman presents to the early pregnancy unit with moderate vaginal bleeding.
An ultrasound is performed, which reports a complete molar pregnancy.
What would be the genetic complement and parental origin of the complete molar pregnancy?

12)

woman has had surgical management of miscarriage and a molar pregnancy has been
confirmed.
Which immunohistochemistry marker is useful for distinguishing between partial and complete
molar pregnancies?

13)

You are reviewing a 36-year-old woman who has undergone a surgical evacuation for a
molar pregnancy. Which one of the following forms part of the FIGO scoring system for
gestational trophoblastic disease (GTD)?

14)

The same 21-yr old woman re-attends hospital 15 weeks later with persistent vaginal
bleeding. Her serum HCG has risen to 6000 mIU/ml

15)

A 24-yr old multiparous woman is diagnosed with GTN 6 months following a partial mole
and has a single 6 cm metastasis in the liver

16)

A woman has had an ultrasound scan and the possibility of a molar pregnancy with a coexisting twin has been raised by the sonographer.
The woman has been referred to a regional fetal medicine centre for further investigations.
What would be the most appropriate investigation?

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