molar pregnancy-early pregnancy care part 2

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A 35-year-old woman presents to the early pregnancy unit with moderate vaginal bleeding.
An ultrasound is performed, which reports a complete molar pregnancy.
What would be the genetic complement and parental origin of the complete molar pregnancy?

A) Haploid: two paternal sets

B) Diploid: two paternal sets

C) Triploid: paternal and maternal

D) Tetraploid: two paternal and two maternal set

E) Diploid: one maternal and one paternal set

A woman has attended the gynaecology clinic to discuss a diagnosis of a molar pregnancy.
What is the definitive method of diagnosis?

A) Clinical assessment

B) Histologic analysis of tissue

C) Serum βHCG levels

D) Ultrasound

E) Urine βHCG levels

The general practitioner calls to ask about the immediate follow-up of a woman who had a
suction evacuation of a complete molar pregnancy. What is your advice?

A) Do a urine or blood test for human chorionic gonadotropins (hCG) every two weeks for eight weeks.

B) Do a urine pregnancy test every two weeks for 24 weeks

C) Do a urine check test every week until it is negative for four successive tests.

D) Do a urine or blood test for hCG every week until it normalizes

E) No need for any follow-up if the urine pregnancy test is negative after one month

A woman has been diagnosed with high-risk gestational trophoblastic neoplasia (GTN) and is
about to receive multiagent chemotherapy. What is the expected cure rate?

A) 65%

B) 75%

C) 85%

D) 95%

E) 100%

A woman has had an ultrasound scan and the possibility of a molar pregnancy with a coexisting twin has been raised by the sonographer.
The woman has been referred to a regional fetal medicine centre for further investigations.
What would be the most appropriate investigation?

A) Fetal blood sampling for βHCG levels of the suspected molar pregnancy

B) Karyotyping of the suspected molar pregnancy

C) Karyotyping of the mother

D) MRI scan

E) Serum βHCG levels

You are reviewing a 36-year-old woman who has undergone a surgical evacuation for a
molar pregnancy. Which one of the following forms part of the FIGO scoring system for
gestational trophoblastic disease (GTD)?

A) Heavy bleeding at the time of surgical evacuation

B) Parity

C) Pregnancy gestation

D) Previous history of childhood malignancy

E) Tumour size

11)

Following appropriate treatment of complete and partial molar pregnancies, what
percentage of women need additional chemotherapy in each case, respectively?

A) 10% and 0.3%.

B) 15% and 0.5%

C) 20% and 1.0%.

D) 25% and 2.0%.

E) 33% and 3.0%

12)

woman has had surgical management of miscarriage and a molar pregnancy has been
confirmed.
Which immunohistochemistry marker is useful for distinguishing between partial and complete
molar pregnancies?

A) P16

B) P53

C) P57

D) P87

E) P96

13)

A woman has undergone surgical management of miscarriage and a partial molar pregnancy
has been confirmed. Referral to a specialist centre is advised.
Where are the three specialist referral centres in the United Kingdom?

A) Aberdeen, Birmingham, London

B) Cardiff, Edinburgh, London

C) Dundee, London, Sheffield

D) Edinburgh, London, Sheffield

E) Glasgow, London, Sheffield

14) What percentage of partial molar pregnancies consist of tetraploid or mosaic conceptions?

A) 10%

B) 25%

C) 50%

D) 75%

E) 90%

16)

A woman has undergone surgical management of miscarriage and the histology confirms
Gestational Trophoblastic Disease (GTD). What is the expected incidence of GTD in the United
Kingdom?

A) 1 in 214 live births

B) 1 in 714 live births

C) 1 in 1254 live births

D) 1 in 2544 live births

E) 1 in 7140 live births

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