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Pharmacology Test Part 1

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1) Which of the following is a DNA Gyrase inhibitor

2) Clavulanic acid is what type of drug?

3)

You review a 17 year old patient in clinic. She has been taking Lamotrigine 125mg BD for 2
years. Last month her GP started her on Microgynon 30 as she started a new sexual
relationship. What would your primary concern be?

4) What is the mode of action of Tranexamic acid?

5) Use of a tocolytic drug is associated with?

6) Fentanyl is approximately how many times more potent than morphine?

7) Which of the following best describes the mechanism of action of Prochlorperazine?

8) What is the half life of Ergometrine?

9) Tamoxifen is which of the following?

10)

A 22 year old patient attends clinic. She reports unprotected sexual intercourse 48 hours
earlier. She is not using any form of contraception. Following discussion you prescribe Ulipristal
30mg as a stat dose. What should you advise regarding vomiting?

11) With regard to opioid receptors. Morphine acts primarily as a potent?

12)

You are asked to prescribe VTE prophylaxis for a 26 year old patient who is 37 weeks pregnant.
She is 72Kg. What dose of Dalteparin would you use?

13)

An 26 year old patient currently 9 weeks pregnant. This is her 1st pregnancy. She has been
suffering with nausea and vomitting that has failed to respond to conservative measures
including ginger, dietary changes and acupuncture. She wants to start medical therapy. Which
of the following is 1st line drug treatment according to NICE guidance?

14)

A women is to undergo elective C‐section. According to RCOG guidance antenatal steroids
should be offered to which group undergoing elective C‐section?

15)

A 66 year old patient sees you in clinic. She has delayed a prolapse repair for 12 months in
order to get good blood pressure control. Her BP in clinic is 132/84. Her medication list is
below:
 Lansoprazole 15mg OD
 Amlodipine 10mg OD
 Ramipril 5mg OD
 Atorvastatin 10mg OD
 Cetirizine 10mg OD PRN
She reports having had a dry cough for the past 3 months and thinks its one of the medications.
Which of her medications is most likely to cause this:

16)

A 31 year old patient undergoes an elective c‐section delivery. You estimate blood loss has
reached 1000ml and you suspect uterine atony is the likely cause. Following bimanual uterine
compression what pharmacological intervention is advised?

17) Which of the following increases the risk of endometrial hyperplasia?

18) Which of the following drugs is most associated with coronary artery spasm?

19) Which of the following best describes the mechanism of action of Ondansetron?

20)

You are reviewing a patient in the uro‐gynaecology clinic. She has had limited response to
conservative measures for her overactive bladder (OAB). You discuss starting Tolterodine.
Which of the following should you warn her are common side effects?

21)

What is the maximum dose of lidocaine that should be used on a 70kg woman who is 12 weeks
pregnant?

22)

A patient is on the ward with a mechanical mitral valve. There is no history of VTE. What is the
target INR?

23)

A 66 year old patient sees you in clinic. She has delayed a prolapse repair for 12 months in
order to get good blood pressure control. Her BP in clinic is 132/84. Her medication list is
below:
 Lansoprazole 15mg OD
 Amlodipine 10mg OD
 Ramipril 5mg OD
 Atorvastatin 10mg OD
 Cetirizine 10mg OD PRN
She reports her lower legs have been swollen for the past 3 months and thinks its one of the
medications. Which of her medications is most likely to cause this:

24)

You review a 26 year old patient in clinic. She has been taking Phenytoin for 6 years and has
good seizure control at her current dose. She has started a new relationship and wants
contraceptive advice. She doesn't mind any form of contraception but doesn't want to use
condoms/barrier methods. According to the UKMEC criteria which of the following would be
most appropriate?

25)

Which of the following women would you advise to take 400mcg of folic acid during the first 12
weeks of pregnancy?

26)

What is the RCOG advice regarding timing of Rhesus Anti‐D Immunoglobulin following
abortion?

27) Which of the following regrading use of tocolytics is true?

28) What is the mechanism of action of Oxytetracycline?

29)

You are asked to prescribe a course of antenatal steroids for a patient undergoing planned C‐
section at 37+0 weeks. Which of the following is the most appropriate regime according to
RCOG guidelines?

30)

A patient is attending for medical abortion. She is 15 weeks gestation. She has no known drug
allergies. Which of the following is the most appropriate regarding antibiotic prophylaxis?

31)

You see a patient who gave birth earlier in the day. She was taken off warfarin during
pregnancy and is currently on LMWH. She intends to breastfeed for the first 6‐8 weeks and
wants advice regarding restarting warfarin. Which of the following is appropriate?

32)

You are reviewing a patient in the uro‐gynaecology clinic. She has had limited response to
conservative measures for her overactive bladder (OAB). You decide to start pharmacological
measures. Which of the following is the most appropriate choice?

33) What is the maximum dose of lidocaine with adrenaline?

34) Cabergoline and Bromocriptine are agonists of which receptor?

35)

Yellow staining of teeth in babies is caused by the mother taking which of the following during
pregnancy?

36) Mifepristone (RU 486) when used to for management of abortion works via what mechanism?

37) A patient is stated on Warfarin due to a Pulmonary Embolism. What is the target INR?

38) Which of the following dugs is a strong inducer of cytochrome P450?

39) Which of the following contraceptives primary mode of action is inhibition of ovulation?

40)

You are called to see a patient in A&E who attended due to finger splinter that has been
removed. The HCA took some routine obs that show her blood pressure to be 162/110. She is
32 weeks pregnant. According to the NICE guidelines which of the following is appropriate?

41)

A patient undergoes medical abortion at 9 weeks gestation. What is the advice regarding
Rhesus Anti‐D Immunoglobulin?

42)

A patient has self referred to the antenatal booking clinic. This is her first pregnancy. She is 25
and based on her LMP is around 6 months pregnant. She takes iron as her iron levels were
borderline low in the past. Apart from that she has no significant past medical problems. She
tells you she is taking the following medications:
 Halibut liver oil capsules 2‐3 daily
 Pregnacare tablets 1 daily
 Ferrous sulphate 200mg OD
 Ascorbic acid 50mg OD
Which of the following is the most appropriate advice regarding her medications

43)

Which anti‐epileptic is associated with the highest risk of congenital malformations if taken in
the 1st trimester?

44) Which of the following best describes the mechanism of action of Cyclizine?

45) Which of the following drugs is most appropriate to use to stimulate stimulate lactation?

46) St Anthony's fire is a potential side effect of which of the following?

47) Warfarin inhibits which clotting factors?

48)

A 26 year patient has been started on methotrexate treatment following diagnosis of
hydatidiform mole. What is the BNF advice regarding frequency of full blood count monitoring
when initiating treatment?

49)

A patient attends for BP monitoring. She is 32 weeks pregnant. Her BP is 155/105. She is taking
labetalol. According to the NICE guidelines which is the most appropriate next agent?

50) What is the current NICE guidance regarding prophylactic antibiotics in C‐section?

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