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Physiology Test (Part 1)

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1) What is the typical oxygen consumption in a 75kg non‐pregnant women?

2) What percentage of haemoglobin is HbF in the newborn?

3) During wound healing the clotting cascade is activated. Which of the following activates the extrinsic pathway?

4) During wound healing the clotting cascade is activated. Which of the following activates the extrinsic pathway?

5) You review a patient who is 34 weeks pregnant. She complains of gradually worsening itching over the past 6 weeks particularly to the hands and feet which is worse at night. You order some bloods. Which of the following would you normally expect to increase in the 3rd  trimester?

6) During wound healing collagen alignment along tension lines is part of which phase?

7) What is the typical weight of a non‐pregnant premenopausal uterus?

8) During pregnancy the GFR changes as follows:

9) According to the UK food standards agency which of the following RDIs (recommended daily intake) is 3 times higher in pregnancy than the non‐pregnant state?

10) Which of the following lung function values is unchanged in pregnancy?

11) In the earliest phase of wound healing platelets are held together by what?

12) In the 3rd trimester anaemia is defined by?

13) Which of the following hormones inhibits Galactopoiesis and Lactogenesis postpartum?

14) Regarding cardiac examination during pregnancy which of the following findings should be considered pathological

15) Following parturition uterine contractions called Afterpains may typically continue for how long?

16) You review a 58 year old patient in clinic. She asks what the results of her recent DEXA scan are. You note her hip BMD hip T‐score is ‐1.4. You note she has a history of olecranon fracture 4 years ago. What is her classification according to WHO criteria?

17) A 52 year old patient attends clinic for the results of her bone density scan. Her T‐score is ‐2.2. She tells you she has previously fractured her 5th metatarsal and patella following a fall from a bike. You diagnose her as:

18) Several mechanisms have been proposed as to what causes closure of the Ductus Arteriosus (DA) at Parturition. Which of the following is the most important in maintaining the patency of the DA during pregnancy?

19) What is the average lifespan of a basophil (white blood cell)?

20) During wound healing the clotting cascade is activated. Which of the following activates the intrinsic pathway?

21) Which of the following tests is used to detect antibodies or complement bound to red blood cell antigens in vivo?

22) At what gestation does the fetus typically start swallowing?

23) Which of the following is the primary stimulator of uterine involution following child birth??

24) At what gestational age does the luteo‐placental shift occur?

25) Lactogenesis at term is stimulated by which hormone?

26) Which of the following is a potent stimulator of Aldosterone

27) Where in the kidney is the majority of Bicarbonate reabsorbed

28) The amniotic fluid volume peaks at around 900ml. At what gestation does the amniotic fluid reach its maximum volume?

29) Regarding blood volume in pregnancy which of the following statements is TRUE?

30) Angiogenesis and collagen deposition are features of which stage of wound healing?

31) A patient asks you how long it will be before her C‐section wound is "at full strength." What is the typical time taken for wounds closed by primary intention to reach full tensile strength?

32) Which of the following is a primary site of Prostaglandin E2 (PGE2) production?

33) Oxytocin causes increased myometrial contractions via which of the following messenger pathways?

34) Which of the following statements regarding thyroid function testing in pregnancy is true?

35) Where in the kidney is the majority of Bicarbonate reabsorbed

36) What is the primary form of haemoglobin in a 18 week old foetus?

37) Placental production of hPL, hCG, Oestragen and Progesterone are examples of which type of mechanism

38) Regarding the use of Erythropoietin (recombinant human erythropoietin AKA rHuEPO) in pregnancy which of the following statements is correct ?

39) Regarding heart rate in pregnancy which of the following statements is true?

40) Regarding the closure of the ductus arteriosus (DA) after birth which of the following most accurately describes the mechanisms leading to closure of the DA?

41) What is the typical volume increase from a non‐pregnant to term uterus?

42) What is the typical peak change in oxygen consumption in a pregnant vs a non‐pregnant women?

43) Which structure is the primary mechanism for shunting blood away from the fetal pulmonary circulation?

44) What is the primary form of haemoglobin in a 6 week old foetus?

45) When using the MDRD formula to calculate GFR (Glomerular filtration rate) which of the following is not factored into the equation?

46) During pregnancy which hormone(s) inhibit lactogenesis?

47) Dilatation of the uterine cervix at parturition is primarily achieved by:

48) Cardiac output is calculated by

49) Where in the kidney is the majority of Sodium and Glucose reabsorbed

50) Pregnant patients are at higher risk of thromboembolism due to a hypercoaguable state. Which of the following clotting factors reduces during pregnancy?

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